Fennel-Lemon Balm Syrup for Alleviating Hot Flash in Post-Menopausal Women, a Pilot Study

Research Journal of Pharmacognosy

article

Mojgan Tansaz¹  Najmeh Faridi²  Homa Hajimehdipoor³  Leila Ara⁴  Behnaz Keramatian⁴  Maryam Hamzeloo-Moghadam³ 

[1]Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences

[2]Midwifery Department, Medical School, Arak University of Medical Sciences

[3]Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences

[4]Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences

关键词: Foeniculum vulgare;    Hot flash;    HPLC;    Melissa officinalis;    menopause;   

DOI  :  10.22127/rjp.2022.328371.1839

学科分类：环境科学（综合）

来源: Iranian Society of Pharmacognosy

【 摘 要 】

Background and objectives: Hot flash is one of the most common problems in post-menopausalwomen. The usual treatment is hormone therapy with estrogen and progesterone, which presents sideeffects such as heart attack, cancer, and depression. In Iranian traditional medicine, some prescriptionshave been recommended for treatment of hot flash; in the present study, a syrup was formulated basedon traditional medicine and the efficacy in hot flash was evaluated in a pilot study in post-menopausalwomen. Methods: Foeniculum vulgare (fennel) and Melissa officinalis (lemon balm) were used forpreparing the syrup. Physicochemical and microbial quality control tests were performed and thesyrup was standardized based on rosmarinic acid and total phenolics content. The effect in postmenopausal women was evaluated in a pilot study with Carpenter Hot Flash Related DailyInterference Scale questionnaire. Results: The results of the quality control and accelerated stabilitytests after six months were in agreement with the acceptance criteria. The pH, density, viscosity, dryresidue, total phenolics and rosmarinic acid contents were 5.29, 1.12 g/cm3, 42.15 cP, 43.43, 4 mg/mL(as pyrogallol) and 1.28 mg/mL, respectively. In the pilot study, the number and intensity of hot flashdecreased (p<0.05); however, there were no significant differences between the number and intensityof night sweating before and after the intervention (p>0.05). Conclusion: Considering the promisingeffect of the formulated syrup on hot flash and the acceptable quality and stability of the product, itcan be suggested in larger clinical trials for confirming the efficacy.

【 授权许可】

CC BY-NC