Chemical Composition and Biological Effects of Pistacia atlantica Desf. Oleoresin Essential Oil

Research Journal of Pharmacognosy

article

Azam Elyasi Ghahfarrokhi¹  Mina Saeedi²  Mahnaz Khanavi¹  Somayeh Mojtabavi⁵  Farzad Kobarfard⁶  Mohammad Ali Faramarzi⁵ 

[1] Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences;Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences;Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences;Faculty of Land and Food Systems, University of British Columbia;Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences;Shahid BeDepartment of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences

关键词: Biological activity;    Chemical analysis;    Essential oil;    oleoresin;    Pistacia Atlantica;   

DOI  :  10.22127/rjp.2022.326106.1830

学科分类：环境科学（综合）

来源: Iranian Society of Pharmacognosy

【 摘 要 】

Background and objectives: The oleoresin of Pistacia atlantica Desf. (known as “Baneh” in Iran)has been frequently used in traditional medicine for its medicinal properties. Herein, P. atlanticaessential oil was investigated for its antimicrobial and α-glucosidase inhibitory activities since αpinene which has been identified as the most abundant component in Pistacia genus oil, hasdemonstrated antimicrobial and anti-α-glucosidase properties. Methods: Fresh oleoresin was collectedfrom Javanroud, Kermanshah, Iran and the essential oil was obtained by Clevenger-type apparatus.The chemical composition of essential oil was identified with GC/MS analysis and compared withthose reported from various regions. The antimicrobial activity was evaluated against various strains(Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans,Saccharomyces cerevisiae, and Lactobacilli spp.) through MIC method. Also, its anti-α-glucosidaseproperty and antioxidant activity by DPPH assay were investigated. Results: GC/MS analysis of theessential oil confirmed the presence of nineteen compounds and among them, α-pinene (64.8%) wasidentified as the major constituent. Also, β-pinene (5.7%) and cis-limonene oxide (4.5%) wererelatively abundant. Our results revealed antimicrobial properties of the “Baneh” essential oil againstvarious bacterial and fungal strains. Moreover, it demonstrated inhibitory activity toward αglucosidase with IC50 value of 41.5 ± 2.5 mg/mL compared with acarbose (IC50=0.5±0.2 mg/mL).DPPH free-radical scavenging activity assay showed antioxidant activity with IC50 value of 155.2 ±1.4 mg/mL compared with quercetin (IC50=250.0±0.0 μg/mL). Conclusion: Pistacia atlanticaoleoresin essential oil depicted satisfactory antimicrobial activity against both Gram-positive andGram-negative strains. However, it demonstrated low antioxidant and α-glucosidase inhibitory effects.

【 授权许可】

CC BY-NC