The Effect of Boswellia Vaginal Gel on Oxidative Stress and Expression of Apoptotic Biomarkers in Vaginal Discharge of Women With Vaginitis

Research Journal of Pharmacognosy

article

Fazele Heydarian Moghadam¹  Mojgan Tansaz¹  Soheila Aminimoghaddam²  Homa Hajimehdipoor³ 

[1] Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences;Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University of Medical Sciences;Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences

关键词: Antioxidant;    Apoptosis;    Boswellia;    oxidative stress;    vaginal candidiasis;   

DOI  :  10.22127/rjp.2021.299234.1763

学科分类：环境科学（综合）

来源: Iranian Society of Pharmacognosy

【 摘 要 】

Background and objectives: Boswellia serrata is an important medicinal plant with strongantioxidant activity. The present study was designed to evaluate the effects of Boswellia vaginal gelon apoptosis and oxidative damage in vaginal mucosal cells of women with vaginal candidiasis.Methods: Ninety-five women with vaginal candidiasis were enrolled in the clinical trial and receivedthe gel for seven consecutive nights. The clinical symptoms of the disease including vaginal secretion,pain, itching, unpleasant odor, and dyspareunia were recorded. Vaginal discharges were collectedbefore and after treatment for the assessment of malondialdehyde (MDA) and total antioxidantcapacity (TAC) using TBAR and FRAP methods, respectively. Expression of Bax, Bcl2, andCaspases-3 genes was surveyed by RT-PCR. Results: Gel therapy significantly decreased thefrequency of pain, burning, itching, dyspareunia and secretion compared to the baseline (p<0.001).Boswellia vaginal gel treatment significantly improved TAC values (from 1.27 ± 0.41 μM/mL to 4.69± 0.53 μM/mL; p<0.001) and decreased MDA values (from 31.47 ± 6.69 nM/L to 13.85 ± 3.72 nM/L;p<0.001). The therapy caused a significant decrease in Bax and Casp3 expression, as well as Bax/Bcl2ratio by 2.34-fold (p=0.018), 2.86-fold (p=0.002), and 12.72-fold (p<0.001), respectively. In contrast,BVG treatment significantly enhanced the expression of Bcl2 expression by 5.42- fold (p<0.001).Conclusion: Vaginal candidiasis is remarkably linked to oxidative stress, reduction of theantioxidants and vaginal mucosal cells apoptosis. Boswellia vaginal gel has potential role to improvevaginitis symptoms by elevating antioxidants capacity, mitigating oxidative stress, as well as downregulating of apoptotic factors.

【 授权许可】

CC BY-NC