Comparing the Effects of Rosemary Extract and Treadmill Exercise on the Hippocampal Function and Antioxidant Capacity in Old Rats

Basic and Clinical Neuroscience

article

Homa Rasoolijazi¹  Sattar Norouzi Ofogh²  Shima Ababzadeh¹  Mehdi Mehdizadeh¹  Fatemeh Shabkhiz² 

[1] Cellular & Molecular Research Center, Iran University of Medical Sciences;Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences

关键词: Cognition;    Antiox idant;    Enzymes;    Aerobic exercise;    Aging;   

DOI  :  10.32598/bcn.12.3.2139.1

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction: A sequence of time-dependent changes can affect the brain’s functional capacity. This study aimed at investigating the effects of Forced Aerobic Exercise (FAE) versus the Rosemary Extract (RE) on the learning abilities and oxidative stress modulation in rats. Methods: Young and old rats received daily FAE and RE for 3 months. Using the Passive Avoidance (PA) test, we evaluated the learning and memory of the rats by Step-Through Latency (STL) score. We measured the Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Catalase (CATA), Malondialdehyde (MDA) enzymes levels, and Total Antioxidant Capacity (TAC) in the hippocampus Results: FAE could significantly increase the STL score (P<0.001) among old rats similar to the rosemary extract consumption. The SOD, GPx, and CATA enzyme activities and the level of TAC significantly increased by the treatments (exercise: P<0.001 for SOD and TAC and P<0.05 for CATA, exercise/rosemary: P<0.001 for all enzymes, and rosemary: P<0.01 for SOD and TAC). Furthermore, the MDA level significantly decreased by the treatments (exercise and exercise/rosemary: P<0.001, rosemary: P<0.01). The partial Pearson test revealed the significant positive correlations between the score of STL (day 2) with the SOD (P<0.01) and TAC (P<0.05) levels and negative correlations between the MDA level and STL score in both days (P<0.05 for the first day and P<0.001 for the second day). Conclusion: Similar to the rosemary extract, FAE could increase the working memory and antioxidants activity in old rats in 3 months.

【 授权许可】

Unknown