Exosomes: Future Perspective in Neurodegenerative Diseases

Caspian Journal of Neurological Sciences

article

Leila Alidoust¹  Adele Jafari² 

[1] Department of Medical Genetics, School of Medicine, Guilan University Of Medical Sciences;Neuroscience Research Center, Department of Physiology, School of Medicine, Guilan University of Medical Sciences

关键词: Exosome;    Neurodegenerative disease;    MicroRNA;    Biomarker;   

DOI  :  10.32598/CJNS.6.23.4

学科分类：社会科学、人文和艺术（综合）

来源: Presses Agronomiques De Gembloux

【 摘 要 】

Neurodegeneration is a progressive and irreversible loss of neuronal cells in specific regions of the brain. Alzheimer Diseases (AD) Parkinson Disease (PD) are the most common forms of neurodegenerative diseases in older people. Exosomes are extracellular nanovesicles that have a key role in physiological processes such as intercellular communication, cell migration, angiogenesis, and anti-tumor immunity. Mounting evidence indicates the role of exosomes in neurodegenerative disorders as possible carriers of disease particles. They have several different potential applications thanks to their unique structure and functions. The present review summarizes recent studies on exosome potentials as a biomarker and therapeutic tool in neurodegenerative diseases. It also provides an overview of the structure and function of exosomes.

【 授权许可】

CC BY-NC