Improving Effect of Ethyl Acetate Fraction of Tanacetum Parthenium Against Brain Oxidative Damage in Pentylenetetrazole-Induced Seizure Model in Mice

Ufuq-i Dānish

article

Fereshteh Asgharzadeh¹  Mahmoud Hosseini²  Farimah Beheshti³  Hassan Rakhshandeh¹  Somaieh Mansouri⁴  Akbar Anaeigoudari⁵ 

[1] Medicinal Plants Pharmacology Research Center, Mashhad University of Medical Sciences;Psychiatric and Behavioral Sciences Research Center, Mashhad University of Medical Sciences;Applied Biomedical Research Center, Mashhad University of Medical Sciences;Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences;Department of Physiology, School of Medicine, Jiroft University of Medical Sciences

关键词: Cortex;    Hippocampus;    Tanacetum parthenium;    Oxidative stress;    Pentylenetetrazole;   

DOI  :  10.32598/hms.27.4.3491.1

学科分类：社会科学、人文和艺术（综合）

来源: Universidade Federal Rural De Pernambuco, Editora

【 摘 要 】

Aims: Oxidative stress plays an essential role in the pathogenesis of seizures. In this study, we investigated the effect of ethyl acetate fraction of Tanacetum parthenium against oxidative brain damage in a pentylenetetrazole(PTZ)-induced seizure model in mice. Methods & Materials: In this experimental study, mice were divided into 6 groups: control, PTZ, and 4 other groups that, besides PTZ, received 25, 50, 100, and 200 mg/kg of the fraction. PTZ (100 mg/kg) and a fraction (30 min before PTZ) were administered intraperitoneally for 3 weeks. Delay in the onset of the minimal clonic seizure (MCS), generalized tonic-clonic seizure (GTCS), and the level of oxidative stress indexes in cortical and hippocampal tissues were measured. Findings: Pretreatment with fraction resulted in postponing the onset seizures in the Fraction+PTZ groups compared to the PTZ group (P<0.05, P<0.01, and P<0.001). In addition, all doses of ethyl acetate fraction decreased the concentration of malondialdehyde (MDA) and increased the level of tom thiol groups and the activity of superoxide dismutase and catalase enzymes in the brain tissues compared to the PTZ group.  Conclusion: Ethyl acetate fraction of Tanacetum parthenium attenuated PTZ-stimulated seizures through improving brain tissue oxidative stress.

【 授权许可】

CC BY-NC