The association between selenium and bone health: a meta-analysis

Bone & Joint Research

article

Haibin Xie¹  Ning Wang¹  Hongyi He¹  Zidan Yang²  Jing Wu²  Tuo Yang³  Yilun Wang¹ 

[1] Department of Orthopaedics, Xiangya Hospital, Central South University;Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University;Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University

关键词: Meta-analysis;    Selenium;    Osteoporosis;    Fracture;    bone mineral density (BMD);    serum;    hip fracture;    osteoporosis;    randomized controlled trials;    dual-energy X-ray absorptiometry;    osteoporotic fracture;    linear regression models;    prospective studies;    type 2 diabetes mellitus;   

DOI  :  10.1302/2046-3758.127.BJR-2022-0420.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

AimsPrevious studies have suggested that selenium as a trace element is involved in bone health, but findings related to the specific effect of selenium on bone health remain inconclusive. Thus, we performed a meta-analysis by including all the relevant studies to elucidate the association between selenium status (dietary intake or serum selenium) and bone health indicators (bone mineral density (BMD), osteoporosis (OP), or fracture).MethodsPubMed, Embase, and Cochrane Library were systematically searched to retrieve relevant articles published before 15 November 2022. Studies focusing on the correlation between selenium and BMD, OP, or fracture were included. Effect sizes included regression coefficient (β), weighted mean difference (WMD), and odds ratio (OR). According to heterogeneity, the fixed-effect or random-effect model was used to assess the association between selenium and bone health.ResultsFrom 748 non-duplicate publications, 19 studies were included. We found a significantly positive association between dietary selenium intake (β = 0.04, 95% confidence interval (CI) 0.00 to 0.07, p = 0.029) as well as serum selenium (β = 0.13, 95% CI 0.00 to 0.26, p = 0.046) and BMD. Consistently, those with higher selenium intake had a lower risk of OP (OR = 0.47, 95% CI 0.31 to 0.72, p = 0.001), and patients with OP had a significantly lower level of serum selenium than healthy controls (WMD = -2.01, 95% CI -3.91 to -0.12, p = 0.037). High dietary selenium intake was associated with a lower risk of hip fracture (OR = 0.44, 95% CI 0.37 to 0.52, p < 0.001).ConclusionSelenium was positively associated with BMD and inversely associated with OP; dietary selenium intake was negatively associated with hip fracture. The causality and therapeutic effect of selenium on OP needs to be investigated in future studies.

【 授权许可】

CC BY-NC