The role of AGEs in pathogenesis of cartilage destruction in osteoarthritis

Bone & Joint Research

article

Chao-Peng He¹  Cheng Chen²  Xin-Chen Jiang³  Hui Li¹  Li-Xin Zhu²  Ping-Xiao Wang¹  Tao Xiao¹ 

[1] Department of Orthopedics, The Second Xiangya Hospital of Central South University;Department of Orthopedics, Second Affiliated Hospital of Hunan Normal University;The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University

关键词: Osteoarthritis;    Advanced glycation end products;    Cartilage extracellular matrix;    Chondrocyte apoptosis;    Chondrocyte autophagy;    Osteoarthritis (OA);    pathogenesis;    cartilage destruction;    chondrocytes;    apoptosis;    autophagy;    degenerative diseases;    Extracellular matrix (ECM) degradation;    progressive joint destruction;    lipid;   

DOI  :  10.1302/2046-3758.115.BJR-2021-0334.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Osteoarthritis (OA) is a degenerative disease resulting from progressive joint destruction caused by many factors. Its pathogenesis is complex and has not been elucidated to date. Advanced glycation end products (AGEs) are a series of irreversible and stable macromolecular complexes formed by reducing sugar with protein, lipid, and nucleic acid through a non-enzymatic glycosylation reaction (Maillard reaction). They are an important indicator of the degree of ageing. Currently, it is considered that AGEs accumulation in vivo is a molecular basis of age-induced OA, and AGEs production and accumulation in vivo is one of the important reasons for the induction and acceleration of the pathological changes of OA. In recent years, it has been found that AGEs are involved in a variety of pathological processes of OA, including extracellular matrix degradation, chondrocyte apoptosis, and autophagy. Clearly, AGEs play an important role in regulating the expression of OA-related genes and maintaining the chondrocyte phenotype and the stability of the intra-articular environment. This article reviews the latest research results of AGEs in a variety of pathological processes of OA, to provide a new direction for the study of OA pathogenesis and a new target for prevention and treatment.

【 授权许可】

CC BY-NC