Infographic: Osteoimmunology mechanism of osteonecrosis of the femoral head

Bone & Joint Research

article

Maoxiao Ma¹  Zhen Tan²  Wuyin Li³  Hong Zhang³  Youwen Liu³  Chen Yue³ 

[1] Hunan University of Chinese Medicine;Department of Bone and Joint Surgery, Peking University Shenzhen Hospital;Department of Orthopedic Surgery, Luoyang Orthopedic Hospital of Henan Province

关键词: Osteoimmunology;    Osteonecrosis of the femoral head.;    Osteonecrosis of the femoral head (ONFH);    inflammatory cytokines;    macrophages;    inflammation;    osteoclast;    femoral head;    interleukin;    blood;    nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB);    pro-inflammatory cytokines;   

DOI  :  10.1302/2046-3758.111.BJR-2021-0536

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Osteonecrosis of the femoral head (ONFH) isa common and refractory disease.1 Increasingevidence suggests inflammatory osteoimmunology plays an indispensable role in the pathogenesis of ONFH.M1 macrophages produce pro-inflammatorycytokines, whereas M2 macrophages produceanti-inflammatory cytokines.2 A disbalance infavour of the M1 phenotype can result in chronicinflammation, which then contributes to ONFH.The shift from M1 to M2 phenotype effectivelydecreases inflammatory cytokines and alleviatesthe symptoms of ONFH.

【 授权许可】

CC BY-NC