Osteoimmunology and osteonecrosis of the femoral head

Bone & Joint Research

article

Maoxiao Ma¹  Zhen Tan²  Wuyin Li³  Hong Zhang³  Youwen Liu³  Chen Yue³ 

[1] Hunan University of Chinese Medicine;Department of Bone and Joint Surgery, Peking University Shenzhen Hospital;Orthopedic Department, Luoyang Orthopedic Hospital of Henan Province

关键词: Osteoimmunology;    Osteonecrosis of the femoral head.;    Osteonecrosis of the femoral head (ONFH);    macrophages;    femoral heads;    inflammation;    pathogenesis;    inflammatory cytokines;    bone remodelling;    interleukins;    osteoclasts;    transforming growth factor beta;   

DOI  :  10.1302/2046-3758.111.BJR-2021-0467.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Osteonecrosis of the femoral head (ONFH)is a refractory disease, which often leads tocollapse of the femoral head.1,2 Each year,approximately 22,000 new cases occur inthe USA and 75,000 to 150,000 in China.3There is no consensus on the pathogenesisof ONFH, despite many studies on the topic.Increasing evidence points to inflammatoryosteoimmunology playing an indispensablerole in the pathogenesis of ONFH.4-8While immune cells such as macrophagesare important for resolving inflammationand promote subsequent tissue repair, theyalso contribute to ONFH, suggesting that thedisease arises as a result of immune systemdysfunction.5,8 Bone biology and immunology have recently been combined in thefield of osteoimmunology to become animportant focus of ONFH research.9 We willsummarize the current understanding of theosteoimmunology of ONFH, focusing onthe important roles of macrophages, T andB cells, and neutrophils, as well as relatedsignalling molecules.

【 授权许可】

CC BY-NC