The role of gut microbiota in bone homeostasis: a systematic review of preclinical animal studies

Bone & Joint Research

article

Jie Li¹  Wing Tung Percy Ho¹  Chaoran Liu¹  Simon Kwoon-Ho Chow¹  Margaret Ip²  Jun Yu³  Hei Sunny Wong³  Wing-Hoi Cheung¹  Joseph Jao Yiu Sung³  Ronald Man Yeung Wong¹ 

[1] Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong;Department of Microbiology, The Chinese University of Hong Kong;Department of Medicine & Therapeutics, The Chinese University of Hong Kong

关键词: Gut microbiota;    Bone;    Osteoporosis;    Gut-bone axis;    Fragility fracture;    Probiotic;   

DOI  :  10.1302/2046-3758.101.BJR-2020-0273.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

AimsThe effect of the gut microbiota (GM) and its metabolite on bone health is termed the gut-bone axis. Multiple studies have elucidated the mechanisms but findings vary greatly. A systematic review was performed to analyze current animal models and explore the effect of GM on bone.MethodsLiterature search was performed on PubMed and Embase databases. Information on the types and strains of animals, induction of osteoporosis, intervention strategies, determination of GM, assessment on bone mineral density (BMD) and bone quality, and key findings were extracted.ResultsA total of 30 studies were included, of which six studies used rats and 24 studies used mice. Osteoporosis or bone loss was induced in 14 studies. Interventions included ten with probiotics, three with prebiotics, nine with antibiotics, two with short-chain fatty acid (SCFA), six with vitamins and proteins, two with traditional Chinese medicine (TCM), and one with neuropeptide Y1R antagonist. In general, probiotics, prebiotics, nutritional interventions, and TCM were found to reverse the GM dysbiosis and rescue bone loss.ConclusionDespite the positive therapeutic effect of probiotics, prebiotics, and nutritional or pharmaceutical interventions on osteoporosis, there is still a critical knowledge gap regarding the role of GM in rescuing bone loss and its related pathways.

【 授权许可】

CC BY-NC