The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development

Bone & Joint Research

article

Zhi Chen¹  Zhiwei Zhang¹  Li Guo¹  Xiaochun Wei¹  Yang Zhang¹  Xiaojian Wang¹  Lei Wei² 

[1] Department of Orthopedics, Second Hospital of Shanxi Medical University;Department of Orthopedics, Warren Alpert Medical School of Brown University

关键词: Histone deacetylase 4;    Chondrocyte hypertrophy;    Endochondral bone development;   

DOI  :  10.1302/2046-3758.92.BJR-2019-0172.R1

学科分类：骨科学

来源: British Editorial Society Of Bone And Joint Surgery

【 摘 要 】

Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4) is the most well-characterized member of the HDAC class IIa family and participates in different signalling networks during development in various tissues by promoting chromatin condensation and transcriptional repression. Studies have reported that HDAC4-null mice display premature ossification of developing bones due to ectopic and early-onset chondrocyte hypertrophy. Overexpression of HDAC4 in proliferating chondrocytes inhibits hypertrophy and ossification of developing bones, which suggests that HDAC4, as a negative regulator, is involved in the network regulating chondrocyte hypertrophy. Overall, HDAC4 plays a key role during bone development and disease. Thus, understanding the role of HDAC4 during chondrocyte hypertrophy and endochondral bone formation and its features regarding the structure, function, and regulation of this process will not only provide new insight into the mechanisms by which HDAC4 is involved in chondrocyte hypertrophy and endochondral bone development, but will also create a platform for developing a therapeutic strategy for related diseases.

【 授权许可】

CC BY-NC