Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review

The journal of physiological sciences

article

Toshinori Yoshihara¹  Hisashi Naito¹ 

[1] Graduate School of Health and Sports Science, Juntendo University

关键词: Growth arrest and DNA damage-inducible 45α;    Histone deacetylase 4;    Exercise intervention;    Aged skeletal muscle;    Sarcopenia;   

DOI  :  10.1186/s12576-020-00783-w

来源: Springer

【 摘 要 】

Aging is associated with a progressive loss of skeletal muscle mass and strength, resulting in frailty and lower quality of life in older individuals. At present, a standard of clinical or pharmacological care to prevent the adverse effects of aging does not exist. Determining the mechanism(s) responsible for muscular atrophy in disused aged muscle is a required key step for the development of effective countermeasures. Studies suggest an age-related differential response of genes and signalings to muscle disuse in both rodents and humans, implying the possibility that effective countermeasures to prevent disuse muscle atrophy may be age-specific. Notably, exercise preconditioning can attenuate disuse-induced muscular atrophy in rodent and human skeletal muscles; however, information on age-specific mechanisms of this exercise-induced protection remains limited. This mini-review aimed to summarize the protective effects of acute exercise preconditioning on muscular atrophy in aged muscle and provide potential mechanisms for its preventive effect on skeletal muscle wasting.

【 授权许可】

Unknown