CTLA-4 polymorphisms associate with breast cancer susceptibility in Asians: a meta-analysis

PeerJ

article

Zhiming Dai¹  Tian Tian¹  Meng Wang¹  Xinghan Liu¹  Shuai Lin¹  Pengtao Yang¹  Kang Liu¹  Yi Zheng¹  Peng Xu¹  Meng Liu¹  Xuewen Yang¹  Zhijun Dai¹ 

[1] Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University;Department of Anesthesia, Second Affiliated Hospital of Xi’an Jiaotong University

关键词: CTLA-4;    Polymorphism;    Breast cancer;    Susceptibility;    Meta-analysis;   

DOI  :  10.7717/peerj.2815

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Previous studies have investigated the association between cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphisms and breast cancer susceptibility, but the results remained inconsistent. Therefore, we evaluated the relationship between four common CTLA-4 polymorphisms and breast cancer risk by a meta-analysis, aiming to derive a comprehensive and precise conclusion. We searched EMBASE, Pubmed, Web of Science, CNKI, and Wanfang databases until July 18th, 2016. Finally, ten eligible studies involving 4,544 breast cancer patients and 4,515 cancer-free controls were included; all these studies were from Asia. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the breast cancer risk in five genetic models. The results indicated that the CTLA-4G (rs231775A (rs3087243G (rs4553808C (rs733618) did not relate to breast cancer risk. In conclusion, CTLA-4 polymorphisms significantly associate with breast cancer susceptibility in Asian populations, and different gene loci may have different effects on breast cancer development. Further large-scale studies including multi-racial populations are required to confirm our findings.

【 授权许可】

CC BY