Divergent effect of fluoxetine on the response to physical or chemical stressors in zebrafish

PeerJ

article

Murilo S. Abreu¹  Ana Cristina V.V. Giacomini¹  Gessi Koakoski¹  Angelo L.S. Piato³  Leonardo J.G. Barcellos¹ 

[1] Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria;Universidade de Passo Fundo;Programa de Pós-Graduação em Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul;Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo

关键词: Cortisol;    Serotonin;    SSRI;    Blood;    Alarm substance;    Stress response;    Physical stressors;    Chemical stressors;   

DOI  :  10.7717/peerj.3330

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus–pituitary–adrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol response in zebrafish. We demonstrate that fluoxetine blunts the response to physical stress, but not to chemical stress.

【 授权许可】

CC BY