Ficus septica plant extracts for treating Dengue virus in vitro

PeerJ

article

Nan-Chieh Huang¹  Wan-Ting Hung²  Wei-Lun Tsai³  Feng-Yi Lai⁴  You-Sheng Lin⁵  Mei-Shu Huang⁵  Jih-Jung Chen⁶  Wei-Yu Lin⁷  Jing-Ru Weng⁸  Tsung-Hsien Chang⁵ 

[1] Department of Family Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital;Section of critical care medicine, Kaohsiung Veteran General Hospital;Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital;Deparment of Nursing, Shu-Zen College of Medicine and Management;Department of Medical Education and Research, Kaohsiung Veterans General Hospital;Faculty of Pharmacy, National Yang-Ming University;Department of Pharmacy, Kinmen Hospital;Department of Marine Biotechnology and Resources, National Sun Yat-sen University;Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology

关键词: Ficus septica;    Dengue virus;    Aichi virus;    Crude extract;   

DOI  :  10.7717/peerj.3448

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the Flaviviridae. DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plants in vitro; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem from Ficus septica Burm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelope picornavirus, Aichi virus, was not inhibited by treatment with F. septica extracts. F. septica may be a candidate antiviral drug against an enveloped virus such as DENV.

【 授权许可】

CC BY