Ficus septica plant extracts for treating Dengue virus in vitro

PeerJ

Feng-Yi Lai¹  Nan-Chieh Huang²  Jing-Ru Weng³  Mei-Shu Huang⁴  Tsung-Hsien Chang⁴  You-Sheng Lin⁴  Wei-Yu Lin⁵  Wei-Lun Tsai⁶  Jih-Jung Chen⁷  Wan-Ting Hung⁸ 

[1] Deparment of Nursing, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan;Department of Family Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan;Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Department of Pharmacy, Kinmen Hospital, Kinmen, Taiwan;Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;Faculty of Pharmacy, National Yang-Ming University, Taipei, Taiwan;Section of critical care medicine, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan;

关键词: Ficus septica;    Dengue virus;    Aichi virus;    Crude extract;   

DOI  :  10.7717/peerj.3448

来源: DOAJ

【 摘 要 】

Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the Flaviviridae. DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plants in vitro; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem from Ficus septica Burm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelope picornavirus, Aichi virus, was not inhibited by treatment with F. septica extracts. F. septica may be a candidate antiviral drug against an enveloped virus such as DENV.

【 授权许可】

Unknown