Neuroblastomas in Eastern China: a retrospective series study of 275 cases in a regional center

PeerJ

article

Yangyang Ma¹  Jicui Zheng²  Jiayan Feng¹  Lian Chen¹  Kuiran Dong²  Xianmin Xiao² 

[1] Department of Pathology, Children’s Hospital of Fudan University;Department of Surgery, Children’s Hospital of Fudan University

关键词: Neuroblastoma;    MYCN status;    Clinicopathological features;    Prognosis;    Surgery;   

DOI  :  10.7717/peerj.5665

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

PurposeMost studies on neuroblastoma (NB) have been conducted in Western countries or Japan. The objective of our study was to analyze clinical and pathological features, MYCN status, surgical methods, and prognosis in Chinese NB patients.MethodsA retrospective, single-center case series study of 275 NBs was implemented. Clinical manifestations, pathological features, MYCN status, and surgical treatment were analyzed. Log-rank test and Cox hazards models were used to assess overall survivals (OSs).ResultsThe cohort consisted of 105 females and 170 males, with an age range of five days to 15 years. MYCN amplification was detected in 21.5% of all cases. The median OS was 15.0 months for MYCN amplified group. The five-year OS rates were 70.8% and 18.3% for MYCN unamplified and amplified groups, respectively, and the comparison of Kaplan–Meier curves for these two groups showed statistical significance (P < .001 by log-rank test). Gross total resection (GTR, n = 111) and subtotal resection (STR, n = 58) were administered in 169 patients at stages 3 and 4 who received chemotherapy and the comparison of Kaplan–Meier curves for different groups in these patients had statistical significance (STR vs. GTR, P = .009; MYCN unamplified vs. amplified, P < .001 by log-rank test, respectively).The multivariate survival analyses showed statistical significance (STR vs. GTR, P = .047; MYCN unamplified vs. amplified, P = .001 by Cox regression model).ConclusionsMYCN amplification is an independently adverse prognostic factor in Chinese NB patients at stages 3 and 4 and GTR is associated with improved OS compared with STR in these patients.

【 授权许可】

CC BY