Maternal temperature exposure impairs emotional and cognitive responses and triggers dysregulation of neurodevelopment genes in fish

PeerJ

article

Violaine Colson¹  Morgane Cousture¹  Danielle Damasceno¹  Claudiane Valotaire¹  Thaovi Nguyen¹  Aurélie Le Cam¹  Julien Bobe¹ 

[1] Fish Physiology and Genomics

关键词: Behavior;    Egg;    Transcriptome;    Trout;    Stress;    Temperature;    Intergenerational;    Cognition;    Emotion;    Auts2;   

DOI  :  10.7717/peerj.6338

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Fish are sensitive to temperature, but the intergenerational consequences of maternal exposure to high temperature on offspring behavioural plasticity and underlying mechanisms are unknown. Here we show that a thermal maternal stress induces impaired emotional and cognitive responses in offspring rainbow trout (Oncorhynchus mykiss). Thermal stress in mothers triggered the inhibition of locomotor fear-related responses upon exposure to a novel environment and decreased spatial learning abilities in progeny. Impaired behavioural phenotypes were associated with the dysregulation of several genes known to play major roles in neurodevelopment, including auts2 (autism susceptibility candidate 2), a key gene for neurodevelopment, more specifically neuronal migration and neurite extension, and critical for the acquisition of neurocognitive function. In addition, our analysis revealed the dysregulation of another neurodevelopment gene (dpysl5) as well as genes associated with human cognitive disorders (arv1, plp2). We observed major differences in maternal mRNA abundance in the eggs following maternal exposure to high temperature indicating that some of the observed intergenerational effects are mediated by maternally-inherited mRNAs accumulated in the egg. Together, our observations shed new light on the intergenerational determinism of fish behaviour and associated underlying mechanisms. They also stress the importance of maternal history on fish behavioural plasticity.

【 授权许可】

CC BY