Prognostic value of mean platelet volume/platelet count ratio in patients with resectable esophageal squamous cell carcinoma: a retrospective study

PeerJ

article

Ji-Feng Feng¹  Chen Sheng¹  Qiang Zhao¹  Pengcheng Chen¹ 

[1] Department of Thoracic Surgery, Zhejiang Cancer Hospital;Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology

关键词: Platelet count;    Esophageal squamous cell carcinoma;    Prognosis;    Mean platelet volume;   

DOI  :  10.7717/peerj.7246

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundMean platelet volume (MPV) to platelet count (PC) ratio (MPV/PC) is a useful indicator in several cancers. However, the role for MPV/PC ratio in esophageal squamous cell carcinoma (ESCC) is still controversial.MethodsA retrospective study was conducted including 277 resectable ESCC patients. The optimal cut-off values were calculated by the X-tile program. The receiver operator characteristic (ROC) curves were also created to show the candidate cut-off points. The comparisons between the X-tile plot and ROC curve were performed. The Kaplan-Meier method was utilized to analyze the cancer-specific survival (CSS). Prognostic factors for CSS were calculated with Cox regression univariate and multivariate analyses.ResultsAccording to the X-tile program, the cut-off values for MPV, PC and MPV/PC ratio were 8.5 (fl), 200 (giga/l) and 0.04, respectively. However, the cut-off values for MPV, PC and MPV/PC ratio by the ROC curves were 8.25 (fl), 243.5 (giga/l) and 0.0410, respectively. The cut-off values were similar between the X-tile and ROC curve. A low MPV/PC ratio level (≤0.04) was associated with poor CSS (22.4% vs. 43.1%, P < 0.001). In multivariate analyses, we found that MPV/PC ratio was an independent predictor for CSS (P < 0.001). When we set the cut-off point using ROC curve, the MPV/PC ratio was still an independent predictor for CSS (P < 0.001).ConclusionThe MPV/PC ratio is a useful predictive indicator in patients with ESCC.

【 授权许可】

CC BY