Study of Mean Platelet Volume As Predictive Index of Neonatal Sepsis

International Journal of Biomedical Research

Rashmi Tiwari¹  Mahtabuddin .¹  R. C. Sharma²  Qazi Rais Ahmed³ 

[1] Assistant Professor, Department of Physiology, G.C.R.G. Institute of Medical Sciences, Lucknow, UP;GCRG Institute of Medical Sciences Bakshi Ka Talab, LucknowIndia;Professor, Department of Physiology, G.C.R.G. Institute of Medical Sciences, Lucknow, UP

关键词: Neonatal Sepsis;    Platelet count;    Mean platelet volume;    C-reactive Protein;   

DOI  :  10.7439/ijbr.v8i4.4083

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Background: Changes in platelet volume indices have been found in infectious diseases. Higher MPV [mean platelet volume] and PDW [platelet development width] values were observed in patients with sepsis compared to the patients who did not have sepsis. It is emphasized that indices might be helpful indices in predicting survival in sepsis.Material and Methods: A total of 54 newborns (sepsis group) and 55 healthy newborns (control group) were evaluated in this study. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results.Results: The study revealed statistically significant MPV and CRP in neonates with sepsis comapred to healthy neonatal subjects on day 1 and 3.Conclusion: It is concluded that increased level of MPV and CRP on day 1 and day 3 (p<0.001) and proposes that these observations can be useful in detecting inflammation in early neonatal life and mortality risk.

【 授权许可】

CC BY