Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer

PeerJ

article

Yongfu Li¹  Yuhan Wei¹  Wenjun Tang²  Jingru Luo²  Minghua Wang³  Haifeng Lin²  Hong Guo⁴  Yuling Ma⁵  Jun Zhang⁶  Qin Li¹ 

[1] Department of Oncology, Beijing Friendship Hospital, Capital Medical University;Department of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province;Department of Pathology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province;Department of Surgery, Beijing Changping District Hospital of Traditional Medicine;Department of Gynecology, Beijing Changping District Hospital of Traditional Medicine;Department of Hematopathology, University of Texas MD Anderson Cancer Center

关键词: Fibrosis;    Fibrotic focus;    Prognosis;    Breast cancer;    Breast invasive ductal carcinoma;    Tumor size;    Vascular invasion;    Lymphatic vessel invasion;    Nottingham prognostic index;    The unfavorable clinicopathological prognostic features;   

DOI  :  10.7717/peerj.8067

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

ObjectiveTo explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer.MethodsA total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed.Results2 cm (P = 0.023), vascular invasion (P = 0.011), lymphatic vessel invasion (P < 0.001) and HER-2+ (P = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 ∼ 12.82], P = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively).ConclusionsThe high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer.

【 授权许可】

CC BY