Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases

PeerJ

article

Jing-Yao Song¹  Xue-Guang Wang²  Zi-Yuan Zhang¹  Lin Che¹  Bin Fan¹  Guang-Yu Li¹ 

[1] Department of Ophthalmology, Second Hospital of Jilin University;Department of Traumatic Orthopedics, Third People’s Hospital of Jinan

关键词: ER stress;    Autophagy;    UPS;    Ophthalmic disease;    Ocular;   

DOI  :  10.7717/peerj.8638

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

ObjectiveEndoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to explore the potential relationship between them and to find their equilibrium sites.DesignThis review illustrates the important role of reasonable regulation of the protein degradation system in ER stress-mediated ophthalmic diseases. There were 128 articles chosen for review in this study, and the keywords used for article research are ER stress, autophagy, UPS, ophthalmic disease, and ocular.Data sourcesThe data are from Web of Science, PubMed, with no language restrictions from inception until 2019 Jul.ResultsThe ubiquitin proteasome system (UPS) and autophagy are important degradation systems in ER stress. They can restore ER homeostasis, but if ER stress cannot be relieved in time, cell death may occur. However, they are not independent of each other, and the relationship between them is complementary. Therefore, we propose that ER stability can be achieved by adjusting the balance between them.ConclusionThe degradation system of ER stress, UPS and autophagy are interrelated. Because an imbalance between the UPS and autophagy can cause cell death, regulating that balance may suppress ER stress and protect cells against pathological stress damage.

【 授权许可】

CC BY