Interthalamic adhesion size in aging dogs with presumptive spontaneous brain microhemorrhages: a comparative retrospective MRI study of dogs with and without evidence of canine cognitive dysfunction

PeerJ

article

Curtis W. Dewey¹  Mark Rishniw¹  Philippa J. Johnson¹  Emma S. Davies¹  Joseph J. Sackman²  Marissa O’Donnell²  Simon Platt⁴  Kelsey Robinson⁴ 

[1] Clinical Sciences, Cornell University College of Veterinary Medicine;Long Island Veterinary Specialists;Rochester Veterinary Specialists and Emergency Services;Department of Small Animal Medicine and Surgery, University of Georgia

关键词: Canine;    Dog;    Brain;    Microhemorrhage;    Cognitive;    Dementia;    MRI;    Amyloid;    Angiopathy;    Alzheimer’s;   

DOI  :  10.7717/peerj.9012

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Objective 9 years) dogs: (1) neurologically impaired dogs with presumptive spontaneous brain microhemorrhages and no clinical evidence of cognitive dysfunction (2) dogs with CCD (3) dogs without clinical evidence of encephalopathy on neurologic examination (control dogs). MR images from 52 aging dogs were reviewed and measurements were obtained of interthalamic adhesion height (thickness) and mid-sagittal interthalamic adhesion area for all dogs, in addition to total brain volume. Interthalamic adhesion measurements, either absolute or normalized to total brain volume were compared between groups. Signalment (age, breed, sex), body weight, presence and number of SBMs, as well as other abnormal MRI findings were recorded for all dogs. Results All interthalamic adhesion measurement parameters were significantly (P < 0.05) different between control dogs and affected dogs. Both dogs with cognitive dysfunction (12/15; 80%) and dogs with isolated brain microhemorrhages had more microhemorrhages than control dogs (3/25; 12%). Affected dogs without cognitive dysfunction had significantly more microhemorrhages than dogs with cognitive dysfunction. In addition to signs of cognitive impairment for the CCD group, main clinical complaints for SBM and CCD dogs were referable to central vestibular dysfunction, recent-onset seizure activity, or both. Geriatric dogs with spontaneous brain microhemorrhages without cognitive dysfunction have similar MRI abnormalities as dogs with cognitive dysfunction but may represent a distinct disease category.

【 授权许可】

CC BY