Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

PeerJ

article

Ke Sha¹  Mengting Chen¹  Fangfen Liu¹  San Xu¹  Ben Wang¹  Qinqin Peng¹  Yiya Zhang¹  Hongfu Xie¹  Ji Li¹  Zhili Deng¹ 

[1] Department of Dermatology, Xiangya Hospital, Central South University;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University;Key Laboratory of Molecular Radiation Oncology Hunan Province, Central South University;Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University;Xiangya International Academy of Translational Medicine, Central South University

关键词: Hair loss;    Hair follicle;    Platelet-rich plasma;    Platelet factor 4;    Androgen receptor;    Dermal papilla cells;   

DOI  :  10.7717/peerj.9867

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor (AR) in human dermal papilla cells in vitro and via hair follicle organ culture. Among the hair growth-promoting and DP-signature genes investigated, PF4 decreased the expression of Wnt5a, Wnt10b, LEF1, HEY1 and IGF-1, and increased DKK1 expression, but did not affect BMP2 and BMP4 expression. Collectively, Our data demonstrate that PF4 suppresses human hair follicle growth possibly via upregulating androgen receptor signaling and modulating hair growth-associated genes, which provides thought-provoking insights into the application and optimization of PRP in treating hair loss.

【 授权许可】

CC BY