Genomic signatures of globally enhanced gene duplicate accumulation in the megadiverse higher Diptera fueling intralocus sexual conflict resolution

PeerJ

article

Riyue Bao¹  Markus Friedrich³ 

[1] Hillman Cancer Center, University of Pittsburgh;Department of Medicine, University of Pittsburgh;Department of Biological Sciences, Wayne State University;School of Medicine, Department of Anatomy and Cell Biology, Wayne State University

关键词: Gene duplication;    Drosophila;    Brachycera;    Genome evolution;    Energy metabolism;    Sexual conflict resolution;    Speciation;    Hexokinase;    Hsp60;    Thioredoxin;   

DOI  :  10.7717/peerj.10012

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Gene duplication is an important source of evolutionary innovation. To explore the relative impact of gene duplication during the diversification of major insect model system lineages, we performed a comparative analysis of lineage-specific gene duplications in the fruit fly Drosophila melanogaster (Diptera: Brachycera), the mosquito Anopheles gambiae (Diptera: Culicomorpha), the red flour beetle Tribolium castaneum (Coleoptera), and the honeybee Apis mellifera (Hymenoptera). Focusing on close to 6,000 insect core gene families containing maximally six paralogs, we detected a conspicuously higher number of lineage-specific duplications in Drosophila (689) compared to Anopheles (315), Tribolium (386), and Apis (223). Based on analyses of sequence divergence, phylogenetic distribution, and gene ontology information, we present evidence that an increased background rate of gene duplicate accumulation played an exceptional role during the diversification of the higher Diptera (Brachycera), in part by providing enriched opportunities for intralocus sexual conflict resolution, which may have boosted speciation rates during the early radiation of the megadiverse brachyceran subclade Schizophora.

【 授权许可】

CC BY