Genomic Exploration of the Hemiascomycetous Yeasts: 20. Evolution of gene redundancy compared to Saccharomyces cerevisiae

FEBS Letters

Bolotin-Fukuhara, Monique⁶  Souciet, Jean-Luc³  Dujon, Bernard²  Saurin, William⁴  Aigle, Michel⁷  Bon, Elisabeth⁷  Potier, Serge³  Artiguenave, François⁴  Weissenbach, Jean⁴  Lépingle, Andrée⁵  Wésolowski-Louvel, Micheline¹  Neuvéglise, Cécile⁵  Wincker, Patrick⁴  Gaillardin, Claude⁵  Ozier-Kalogeropoulos, Odile²  Casaregola, Serge⁵  Malpertuy, Alain²  Tekaia, Fredj²  Durrens, Pascal⁷  Brottier, Philippe³  Blandin, Gaëlle²  de Montigny, Jacky³  Llorente, Bertrand²  Toffano-Nioche, Claire⁶ 

[1] Microbiologie et Génétique ERS 2009, CNRS/UCB/INSA, bat. 405 R2, Université Lyon I, F-69622 Villeurbanne Cedex, France;Unité de Génétique Moléculaire des Levures (URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie), Institut Pasteur, 25 rue du Docteur Roux, F-75724 Paris Cedex 15, France;Laboratoire de Génétique et Microbiologie, UPRES-A 7010 UPL/CNRS, Institut de Botanique, 28 rue Goethe, F-67000 Strasbourg, France;Génoscope, Centre National de Séquençage, 2 rue Gaston Crémieux, BP 191, Evry Cedex, France;Collection de Levures d'Intérêt Biotechnologique, Laboratoire de Génétique Moléculaire et Cellulaire, INRA UMR 216, CNRS URA 1925, INA-PG, BP01, F-78850 Thiverval-Grignon, France;Institut de Génétique Moléculaire (UMR 8621), Bat 400, Université Paris-Sud, F-91405 Orsay Cedex, France;Laboratoire de Biologie Cellulaire de la Levure, IBGC, 1 rue Camille Saint-Säens, F-33077 Bordeaux Cedex, France

关键词: Paralogue;    Orthologue;    Genome evolution;    Gene duplication;    Gene deletion;   

DOI  :  10.1016/S0014-5793(00)02291-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have evaluated the degree of gene redundancy in the nuclear genomes of 13 hemiascomycetous yeast species. Saccharomyces cerevisiae singletons and gene families appear generally conserved in these species as singletons and families of similar size, respectively. Variations of the number of homologues with respect to that expected affect from 7 to less than 24% of each genome. Since S. cerevisiae homologues represent the majority of the genes identified in the genomes studied, the overall degree of gene redundancy seems conserved across all species. This is best explained by a dynamic equilibrium resulting from numerous events of gene duplication and deletion rather than by a massive duplication event occurring in some lineages and not in others.

【 授权许可】

Unknown