Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study

PeerJ

article

Hon-Ke Sia¹  Chew-Teng Kor³  Shih-Te Tu¹  Pei-Yung Liao¹  Yu-Chia Chang² 

[1]Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital

[2]Department of Healthcare Administration, Asia University

[3]Internal Medicine Research Center, Changhua Christian Hospital

[4]Department of Medical Research, China Medical University Hospital, China Medical University

关键词: Predictor;    Treatment failure;    Newly diagnosed;    Type 2;    Diabetes;    First year;    Glycemic control;    Primary care;    HbA1c;    Risk factor;   

DOI  :  10.7717/peerj.11005

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundDiabetes patients who fail to achieve early glycemic control may increase the future risk of complications and mortality. The aim of the study was to identify factors that predict treatment failure (TF) during the first year in adults with newly diagnosed type 2 diabetes mellitus (T2DM).Methods7% at the end of 1-year observation. A subgroup analysis of 2,392 patients with baseline HbA1c ≥8% was performed. Multivariable logistic regression analysis using backward elimination was applied to establish prediction models.ResultsOf all study participants, 1,439 (33.6%) were classified as TF during the first year. For every 1% increase in baseline HbA1c, the risk of TF was 1.17 (95% CI 1.15–1.20) times higher. Patients with baseline HbA1c ≥8% had a higher rate of TF than those with HbA1c <8% (42.0 vs 23.0%, p < 0.001). Medication adherence, self-monitoring of blood glucose (SMBG), regular exercise, gender (men), non-insulin treatment, and enrollment during 2010–2017 predicted a significant lower risk of TF in both of the primary and subgroup models.ConclusionsNewly diagnosed diabetes patients with baseline HbA1c ≥8% did have a much higher rate of TF during the first year. Subgroup analysis for them highlights the important predictors of TF, including medication adherence, performing SMBG, regular exercise, and gender, in achieving glycemic control.

【 授权许可】

CC BY