Research progress in toxicological effects and mechanism of aflatoxin B 1 toxin

PeerJ

article

Congcong Li¹  Xiangdong Liu²  Jiao Wu¹  Xiangbo Ji³  Qiuliang Xu¹ 

[1] College of Animal Science and Technology, Henan University of Animal Husbandry and Economy;Huazhong Agricultural University, Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs;Henan University of Animal Husbandry and Economy, Henan Key Laboratory of Unconventional Feed Resources Innovative Utilization

关键词: Mycotoxins;    Aflatoxin B1;    Toxicities;    Mechanisms;    Regulation;   

DOI  :  10.7717/peerj.13850

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Fungal contamination of animal feed can severely affect the health of farm animals, and result in considerable economic losses. Certain filamentous fungi or molds produce toxic secondary metabolites known as mycotoxins, of which aflatoxins (AFTs) are considered the most critical dietary risk factor for both humans and animals. AFTs are ubiquitous in the environment, soil, and food crops, and aflatoxin B1(AFB1) has been identified by the World Health Organization (WHO) as one of the most potent natural group 1A carcinogen. We reviewed the literature on the toxic effects of AFB1 in humans and animals along with its toxicokinetic properties. The damage induced by AFB1 in cells and tissues is mainly achieved through cell cycle arrest and inhibition of cell proliferation, and the induction of apoptosis, oxidative stress, endoplasmic reticulum (ER) stress and autophagy. In addition, numerous coding genes and non-coding RNAs have been identified that regulate AFB1 toxicity. This review is a summary of the current research on the complexity of AFB1 toxicity, and provides insights into the molecular mechanisms as well as the phenotypic characteristics.

【 授权许可】

CC BY