期刊论文详细信息
BMC Cancer 卷:19
Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China
Kathy S. Xue1  Jia-Sheng Wang1  Lili Tang1  Xu Hu2  Guiju Sun3  Shaokang Wang3 
[1] Department of Environmental Health Science, College of Public Health, University of Georgia;
[2] Huaian District Center for Disease Control and Prevention;
[3] Southeast University School of Public Health;
关键词: Aflatoxin B1;    Co-exposure;    Fumonisin B1;    Esophageal cancer;    Molecular epidemiology;    Mycotoxins;   
DOI  :  10.1186/s12885-019-6439-x
来源: DOAJ
【 摘 要 】

Abstract Background Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play in the etiology of ESCC are largely unknown. Methods A mycotoxin biomarker-incorporated, population-based case-control study was performed in Huaian area, Jiangsu Province, one of the two high-risk areas in China. Exposure biomarkers of aflatoxins (AF) and fumonisins (FN) were quantitatively analyzed using HPLC-fluorescence techniques. Results Among the cases (n = 190), the median levels of AF biomarker, serum AFB1-lysine adduct, and FN biomarker, urinary FB1, were 1.77 pg/mg albumin and 176.13 pg/mg creatinine, respectively. Among the controls (n = 380), the median levels of AFB1-lysine adduct and urinary FB1 were 1.49 pg/mg albumin and 56.92 pg/mg creatinine, respectively. These mycotoxin exposure biomarker levels were significantly higher in cases as compared to controls (p <  0.05 and 0.01, respectively). An increased risk to ESCC was associated with exposure to both AFB1 and FB1 (p <  0.001 for both). Conclusions Mycotoxin exposure, especially to AFB1 and FB1, was associated with the risk of ESCC, and a greater-than-additive interaction between co-exposures to these two mycotoxins may contribute to the increased risk of ESCC in Huaian area, China.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次