Proteomic profile of serum from patients with schizophrenia spectrum disorders

PeerJ

article

Elena Dmitrieva¹  Liudmila Smirnova¹  Alexander Seregin¹  Victor Zgoda²  Arkadij Semke¹  Svetlana Ivanova¹ 

[1] Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences;Laboratory of Systems Biology, Institute of Biomedical Chemistry

关键词: Schizophrenia;    Schizotypal disorder;    Proteomics;    Mass spectrometry;    System biology;   

DOI  :  10.7717/peerj.13907

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

This article describes the most likely classes of proteins and molecular processes that specifically characterize schizophrenic spectrum disorders such as simple and paranoid schizophrenia, schizotypal disorder, and acute polymorphic psychotic disorder (APPD). The identification of patients’ serum proteins was carried out using mass spectrometry. For patients with paranoid schizophrenia, the proteins responsible for translation and transcription are characteristic. A significant part of the proteins of patients with simple schizophrenia regulate the cell’s main metabolic and transport processes. These are proteins of the receptor system, vesicular transport, and extracellular matrix, which mainly carry out catabolic processes. The proteins of patients with schizotypal disorder mostly coincided with the classes of other patients, apart from chaperone proteins, which were not found in other studied groups. These proteins are mainly involved in anabolic processes. The main classes of proteins found in patients with APPD are responsible for the metabolism of nucleic acids. Active apoptosis processes were also revealed in these patients. These results from our basic knowledge about the molecular mechanisms of the pathogenesis of these disorders.

【 授权许可】

CC BY