Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review

PeerJ

article

Cuihua Liu¹  Zunjiang Li²  Botao Li¹  Wei Liu¹  Shizhong Zhang¹  Kuncheng Qiu¹  Wei Zhu² 

[1] Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province;The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province

关键词: Ferroptosis;    Mitophagy;    Relationship;    Myocardial ischemia reperfusion injury;    Mechanism;   

DOI  :  10.7717/peerj.14952

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment.

【 授权许可】

CC BY