Potential drug-drug interactions and their associated factors in hospitalized COVID-19 patients with comorbidities

PeerJ

article

Imanda Dyah Rahmadani¹  Sylvi Irawati³  Yosi Irawati Wibowo³  Adji Prayitno Setiadi³ 

[1] Fakultas Farmasi, Universitas Surabaya;Department of Pharmacy, Hospital of Muhammadiyah Lamongan;Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya;Center for Medicines Information and Pharmaceutical Care;Pusat Informasi Obat dan Layanan Kefarmasian ,(PIOLK)), Faculty of Pharmacy, Universitas Surabaya

关键词: COVID-19;    Inpatients;    Comorbidity;    Drug interactions;    Risk factors;   

DOI  :  10.7717/peerj.15072

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundHospitalized COVID-19 patients with comorbidities receive more complex drug therapy. This increases the probability of potential drug-drug interactions (pDDIs). Studies on pDDIs in hospitalized patients with COVID-19 in countries with limited resources like Indonesia during the later period of the disease are still limited. This study aims to identify the pattern of pDDIs in hospitalized COVID-19 patients with comorbidities and their associated factors, especially in the second wave of the disease in Indonesia.MethodsThis study was a longitudinal-retrospective study observing hospitalized COVID-19 patients with comorbidities using medical record data in June–August 2021 at a public hospital in a region in Indonesia. pDDIs were identified using the Lexicomp® database. Data were descriptively analyzed. Factors associated with important pDDIs were analyzed in multivariate logistic regression model.ResultsA total of 258 patients with a mean age of 56.99 ± 11.94 years met the inclusion criteria. Diabetes mellitus was the most common comorbidity experienced by 58.14% of the patients. More than 70% of the patients had one comorbidity and the average number of administered drugs was 9.55 ± 2.71 items per patient. Type D pDDIs, which required modification of therapeutic regimens, amounted to 21.55% of the total interactions. Only the number of drugs was significantly and independently associated with type D pDDIs (adjusted odds ratio 1.47 [1.23–1.75], p < 0.01).ConclusionThe drugs involved in the pDDIs of hospitalized COVID-19 patients with comorbidities may differ depending on the disease periods, hospital settings, or countries. This study was small, single center, and of short duration. However, it may give a glimpse of important pDDIs during the delta variant of COVID-19 in a similar limited-resource setting. Further studies are needed to confirm the clinical significance of these pDDIs.

【 授权许可】

CC BY