L-tyrosine metabolic pathway in microorganisms and its application in the biosynthesis of plant-derived natural products

World Journal of Traditional Chinese Medicine

article

Yi-Wen Zhang¹  Feng Nie¹  Xiao-Yu Zheng²  Shu-Juan Zhao¹ 

[1] The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine;Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine

关键词: Biosynthesis;    Escherichia coli;    L-tyrosine;    Saccharomyces cerevisiae;   

DOI  :  10.4103/wjtcm.wjtcm_16_22

学科分类：内科医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

L-tyrosine, an aromatic amino acid, is an important upstream precursor for the synthesis of a series of valuable natural products such as flavonoids and phenolic acids. In recent years, regulation of the L-tyrosine metabolic pathway has been devoted to enhancing the production of L-tyrosine and the derived bioactive compounds in microorganisms, usually by increasing the supply of precursors, blocking competitive routes, and modulating the transport system. Here, we reviewed the strategies to promote L-tyrosine production in microbial hosts and the common strategies to produce bioactive compounds in engineered Escherichia coli and Saccharomyces cerevisiae to better understand and utilize the L-tyrosine metabolic pathway for microbial overproduction of diverse valuable aromatic compounds in the future.

【 授权许可】

CC BY-NC-SA