Genetic association of rs7754840 and rs7756992 polymorphisms in the CDKAL1 gene and gestational diabetes mellitus in selected Filipino pregnant women

Asian Pacific Journal of Reproduction

article

Pineda-Cortel, Maria Ruth B.¹  Baybayan, Karlo¹  Bello, Peter Louie¹  Camenforte, Latiffa Lois¹  Ching, Stefany Jane¹  Conti, Kathleen¹  Ignacio, Jeremiah Jose¹  Diaz, Jiovanni¹  Villavieja, Adrian²  Pandac, Jefferyl Kae²  Alejandro, Emilyn U.¹ 

[1] Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas;The Graduate School, University of Santo Tomas;Research Center for the Natural and Applied Sciences, University of Santo Tomas;Institute of Clinical Laboratory Sciences, Silliman University

关键词: Gestational diabetes mellitus;    GDM;    Single nucleotide polymorphism;    SNP;    Genetic association;    rs7756992;    rs7754840;    CDKAL1;    Filipino pregnant women;   

DOI  :  10.4103/2305-0500.321123

学科分类：兽医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Objective:  To investigate the possible association between rs7754840 and rs7756992 polymorphisms of CDKAL1 gene and susceptibility to gestational diabetes mellitus (GDM) in a Filipino pregnant population. Methods:  A total of 101 patients with GDM and 99 women without GDM were included. Two CDKAL1 gene single nucleotide polymorphisms (SNPs), namely rs7754840 and rs7756992, were genotyped by using TaqMan allelic discrimination assays. Mann-Whitney U test, median and interquartile range were used to describe physical and biochemical characteristics. The differences in the genotype and allele distribution of the target genetic variants among the two groups of participants were assessed by using Chi-square test. Conformity to Hardy-Weinberg equilibrium was tested prior to conducting further analysis. Multiple logistic regression model was used to investigate the effects of the genotype models on GDM development. Results:  There was no observed correlation between the genotypes of the rs7754840 SNP and oral glucose tolerance test parameters. Consequently, there was no significant association between genetic models of the rs7754840 SNP and GDM risk (additive OR 1.43, 95% CI 0.82-2.50, P=0.21; dominant OR 1.21, 95% CI 0.57-2.59, P=0.62; recessive OR 1.63, 95% CI 0.86-3.09, P=0.13). Conclusions:  The results of this study suggest no association between CDKAL1 gene variant rs7754840 and GDM development in Filipino pregnant women. Further studies with a larger population should be performed to validate our findings.

【 授权许可】

CC BY-NC-SA