Analysis of foveal microvascular abnormalities in various stages of diabetic retinopathy using optical coherence tomography angiography

Kerala Journal of Ophthalmology

article

Hemalatha, B. C.¹  Kalpana, B. N.²  Shilpa, Y. D.¹  Ravi, B.¹  Argekar, Vijayalaxmi R.¹  Hithashree, H. R.¹  Dixith, V. Sahana¹ 

[1] Assistant Professor, Department of Ophthalmology, Bangalore Medical College and Research Institute;Department of Retina, Bangalore Medical College and Research Institute

关键词: Diabetic macular edema;    diabetic retinopathy;    foveal avascular zone;    optical coherence tomography angiography;    superficial capillary plexus;    vessel density;   

DOI  :  10.4103/kjo.kjo_195_20

学科分类：社会科学、人文和艺术（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Purpose:  Diabetic retinopathy (DR) remains a leading cause of vision loss in the adult population. The purpose of our study was to analyze and co-relate diabetic retinopathy-related micro-vascular changes using Optical Coherence Tomography Angiography (OCTA) in various stages of diabetic retinopathy. Methods:  One hundred and twenty eyes of diabetic patients were categorized into three groups of forty each. Group-A included eyes without retinopathy, Group-B included eyes with Non-Proliferative Diabetic Retinopathy and Group-C included eyes with proliferative DR. Apart from complete ocular examination, foveal avascular zone parameters were analyzed using OCTA. Results:  0.001). 9 Vascular density (VD) significantly decreases in eyes with the progressive stage of DR. Foveal avascular zone showed a significant increase in area, perimeter, and circularity in the eyes with PDR compared to other groups. Conclusion:  FAZ metrics showed significant changes proportional to diabetic retinopathy stages. Vascular density and perfusion density parameter analysis by OCTA could be used as early biomarkers in predicting the risk of diabetic retinopathy progression.

【 授权许可】

CC BY-NC-SA