Inter-examiner and intra-examiner reliability of optical coherence tomography angiography in vascular density measurement of retinal and choriocapillaris plexuses in healthy children aged 6–15 years

Frontiers in Medicine

Medicine

Jinjin Yu¹  Jinhai Huang¹  Hongxian Pan²  Qinmei Wang²  Feifei Fan²  Kai Diao²  Xiaomin Huang²  Mingyu Yao²  Jiawei Li²  Weiwei Lu²  Ruru Chen²  Yizhou Yang²  Hengli Lian² 

[1] Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China;NHC Key Laboratory of Myopia, Fudan University, Shanghai, China;Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Beijing, China;Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China;School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China;

关键词: capillary plexus;    children;    foveal avascular zone;    macula;    optical coherence tomography angiography;    vascular density;   

DOI  :  10.3389/fmed.2023.1161942

 received in 2023-02-08, accepted in 2023-04-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThis study aimed to test the inter-examiner and intra-examiner reliability of macular vascular density (VD) measurement of retinal and choriocapillaris plexuses in healthy children using optical coherence tomography angiography (OCTA).Materials and methodsNinety-two school children were prospectively recruited. Macular OCTA images (6 × 6 mm2) were obtained thrice by two examiners using the RTVue-XR Avanti OCT system. The coefficient of variation (COV), intraclass correlation coefficient (ICC), and Bland–Altman plots were used to evaluate the repeatability and reproducibility.ResultsNinety participants aged 6–15 years were enrolled; two participants were excluded because of low-quality images. In the retina, the reproducibility and repeatability of VD became poorer from superficial to deep retinal capillary plexus (superficial: COV = 4.61–11.11%; intermediate: COV = 7.73–14.15%; deep: COV = 14.60–32.28%). For both reproducibility and repeatability, the ICC ranged from moderate to high (superficial plexus: ICC = 0.570–0.976; intermediate plexus: ICC = 0.720–0.968; deep plexus: ICC = 0.628–0.954). In the choroid, the inter-examiner reproducibility and intra-examiner repeatability of the VD measurement of choriocapillaris were excellent in the macula, fovea, parafovea, and perifovea (COV = 1.00–6.10%; ICC = 0.856–0.950). The parameters of the foveal avascular zone (FAZ) also showed significant reproducibility and repeatability (COV = 0.01–0.21%; ICC = 0.743–0.994).ConclusionThe VD measurements of the choriocapillaris and FAZ parameters using OCTA showed excellent inter-examiner and intra-examiner reliability in school children. The reproducibility and repeatability of the VD of three retinal capillary plexuses depended on the depth of the retinal capillary plexus.

【 授权许可】

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Copyright © 2023 Diao, Huang, Yao, Li, Fan, Pan, Yu, Yang, Lu, Lian, Wang, Huang and Chen.