Role of interleukin gene polymorphism in patients with chronic and aggressive periodontitis: A narrative review

Indian Journal of Dental Sciences

article

Shukla Preeti¹  Batra Jyoti¹  Bali Shweta²  Shukla Pradeep³ 

[1] Department of Biochemistry, Santosh Medical College;Department of Periodontology, Santosh Medical College;Department of Periodontology, DJ College of Dental Sciences and Research

关键词: Aggressive periodontitis;    chronic periodontitis;    genetics;    interleukins;    polymorphisms;   

DOI  :  10.4103/ijds.ijds_90_21

学科分类：生物科学（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Periodontitis is a microbial disease of tooth-supporting tissues that results in progressive destruction of surrounding soft and hard tissues with eventual loss of tooth or tooth mobility. A comprehensive literature search was performed by using the keywords: periodontitis, periodontal disease, combined with the word genes, mutation, or polymorphism. Gene polymorphism studies with a reported genotype frequency in chronic periodontitis (CP) and aggressive periodontitis (AgP) patients were searched and reviewed. There has been a growing evidence of polymorphisms in the interleukin (IL)-1, IL-4, IL-6, IL-10, IL-12, and tumor necrosis factor-alpha with CP and AgP in certain populations. However, carriage rates of the rare (R) allele of any polymorphism varied considerably among studies, and most of the studies appeared underpowered and did not correlate for other risk factors, hence furthermore researches are required including large sample size, different races, genotypes, and other risk factors which were found to be influential in expression and severity of CP and AgP to get a more comprehensive insight into the contribution of IL gene polymorphisms in CP and AgP.

【 授权许可】

CC BY-NC-SA