Pagetoid spread of urothelial carcinoma controlled without resection

IJU Case Reports

article

Shutaro Yamamoto¹  Tatsuya Shimomura¹  Kanako Kasai¹  Taisuke Yamazaki³  Yuki Enei¹  Yusuke Koike²  Toshihiro Ito⁴  Tohru Harada⁵  Nozomu Furuta¹  Takahiro Kimura³ 

[1] Department of Urology, The Jikei University Daisan Hospital;Department of Urology, JR Tokyo General Hospital;Department of Urology, The Jikei University School of Medicine;Department of Dermatology, The Jikei University Daisan Hospital;Department of Pathology, The Jikei University Daisan Hospital

关键词: chemotherapy;    extramammary Paget's disease;    urinary bladder neoplasms;    vulva;    vulvectomy;   

DOI  :  10.1002/iju5.12555

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

IntroductionExtramammary Paget's disease is an eczematous skin condition that affects the vulva and perineum. Extramammary Paget's disease secondary to urothelial carcinoma is a rare condition that is typically treated with invasive surgical resection of the lesion. Case presentationAn 80-year-old woman with a 7-year history of urothelial carcinoma presented with erythema of the labia majora. Immunostaining of skin biopsy specimens suggested extramammary Paget's disease secondary to urothelial carcinoma. The patient did not consent to resection of the lesion. Nine cycles of first-line platinum-based chemotherapy for metastatic urothelial carcinoma were administered. As tumor cells remained after systemic chemotherapy, pembrolizumab will be administered to the patient for treating residual extramammary Paget's disease. ConclusionPlatinum-based chemotherapy can control extramammary Paget's disease secondary to urothelial carcinoma.

【 授权许可】

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