Extramammary Paget's disease of the glans penis secondary to urethral recurrence of bladder carcinoma after radical cystectomy: A case report

IJU Case Reports

Masashi Honda¹  Shuichi Morizane¹  Atsushi Takenaka¹  Katsuya Hikita¹  Ryoma Nishikawa¹  Toshihiko Masago² 

[1] Department of Urology Tottori University Faculty of Medicine Yonago Japan;Department of Urology Yonago Medical Center Yonago Tottori Japan;

关键词: bladder neoplasms;    extramammary Paget's disease;    penectomy;    penis;    urethral neoplasms;   

DOI  :  10.1002/iju5.12077

来源: DOAJ

【 摘 要 】

Introduction Extramammary Paget's disease of the vulva secondary to urothelial carcinoma is rare. It is important to determine whether extramammary Paget's disease is primary or secondary, because the appropriate treatment strategies differ. We report a case of penile extramammary Paget's disease secondary to urothelial carcinoma recurrence. Case presentation A 75‐year‐old man who was diagnosed with bladder carcinoma and received urethra‐sparing radical cystectomy 5 years ago presented with erythema and red spots in the glans penis. Immunostaining (cytokeratin 7 and cytokeratin 20) of skin biopsy specimens suggested a secondary extramammary Paget's disease that originated from the urothelial carcinoma. Under urethroscopy, urethral recurrence was also suspected. A total penectomy was performed, and a final diagnosis of urothelial carcinoma recurrence and secondary extramammary Paget's disease of the glans penis were established. Conclusion Using immunostaining, the differential diagnosis between primary and secondary extramammary Paget's disease is more accurate. Secondary extramammary Paget's disease should be considered when a skin lesion is present on the penis of patients with urothelial carcinoma.

【 授权许可】

Unknown