COVID-19-associated Brugada pattern electrocardiogram: Systematic review of case reports

Annals of noninvasive electrocardiology: the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

article

Kevin Liu¹  Kai Chen¹  Ekin C. Uzunoglu¹  Azeem Rathore¹  Tanya Deol¹  Ele Wu¹  Claude S. Elayi²  Prakash G. Suryanarayana¹  Stephen G. Keim¹  John N. Catanzaro¹ 

[1]Department of Medicine, Division of Cardiology, Section of Electrophysiology, University of Florida Health Science Center

[2]CHI Saint Joseph Hospital – Cardiology

关键词: Brugada;    COVID;    electrocardiogram;   

DOI  :  10.1111/anec.13051

来源: Wiley

【 摘 要 】

AimsTo summarize published case reports of patients diagnosed with coronavirus disease 2019 (COVID-19) and Brugada pattern electrocardiogram (ECG). MethodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist were followed. A literature search was conducted using PubMed, EMBASE, and Scopus up until September 2021. The incidence, clinical characteristics, and management outcomes of COVID-19 patients with a Brugada pattern ECG were identified. ResultsA total of 18 cases were collected. The mean age was 47.1 years and 11.1% were women. No patients had prior confirmed diagnosis of Brugada syndrome. The most common presenting clinical symptoms were fever (83.3%), chest pain (38.8%), shortness of breath (38.8%), and syncope (16.6%). All 18 patients presented with type 1 Brugada pattern ECG. Four patients (22.2%) underwent left heart catheterization, and none demonstrated the presence of obstructive coronary disease. The most common reported therapies included antipyretics (55.5%), hydroxychloroquine (27.7%), and antibiotics (16.6%). One patient (5.5%) died during hospitalization. Three patients (16.6%) who presented with syncope received either an implantable cardioverter defibrillator or wearable cardioverter defibrillator at discharge. At follow-up, 13 patients (72.2%) had resolution of type 1 Brugada pattern ECG. ConclusionCOVID-19-associated Brugada pattern ECG seems relatively rare. Most patients had resolution of the ECG pattern once their symptoms have improved. Increased awareness and timely use of antipyretics is warranted in this population.

【 授权许可】

Unknown