期刊论文详细信息
Cellular Therapy and Transplantation | |
GC-02. Resistance to anti-CD19 CAR T-cell therapy. Case report | |
article | |
Alexandr A. Migas1  Tatsiana V. Shman1  Anna V. Klych1  Elena S. Lukojko1  Evgeniy V. Dmitriev1  Lyudmila V. Movchan1  Mikalai A. Katsin2  Inna V. Proleskovskaya1  Olga V. Aleinikova3  | |
[1] Belarusian Research Center for Pediatric Oncology;Vitebsk Regional Center of Clinical Oncology;Dmitry Rogachev National Research Center of Pediatric Hematology | |
关键词: Total body irradiation; allo-HSCT; children; hemoblastoses; radiation therapy.; | |
DOI : 10.18620/ctt-1866-8836-2022-11-3-1-132 | |
学科分类:肿瘤学 | |
来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf | |
【 摘 要 】
Primary resistance to CAR T-cell therapy occurs in 10-20% of pediatric B-ALL cases [PA Atilla, 2022]. Impaired functional activity of CAR T-cells and biological properties of leukemic cells are among the causes of described phenomenon. Anti-CD19 CAR T-cell therapy was carried out at Belarusian Research Center for Pediatric Oncology, Hematology and Immunology (BRCPOHI) for 8 B-ALL patients with one case proven to have primary resistance to the given therapy.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202307080001373ZK.pdf | 97KB | download |