PO-02. The first St. Petersburg experience of using total body irradiation as part of conditioning regimes prior to allogeneic hematopoietic stem cells transplantation in children

Cellular Therapy and Transplantation

article

Maria A. Rusina¹  Yulia V. Dinikina¹  Alexey V. Mikhailov²  Svetlana I. Lapaeva¹  Anna Yu. Smirnova¹  Andrey S. Egorov¹  Yulia K. Toshina¹  Daria A. Morgacheva¹  Nikolay A. Vorobyov²  Nikita A. Kataev²  Anton V. Kubasov² 

[1] Almazov National Medical Research Centre;LDC Dr. Berezin Medical Institute;North-Western I. I.Mechnikov State Medical University;St. Petersburg State University

关键词: Total body irradiation;    allo-HSCT;    children;    hemoblastoses;    radiation therapy.;   

DOI  :  10.18620/ctt-1866-8836-2022-11-3-1-132

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Some myeloablative total body irradiation (TBI)/total lymphoid irradiation (TLI) – based conditioning regimens prior to allogeneic hematopoietic stem cell transplantation are an effective treatment modality for some pathologic conditions. However, the issues of early and long-term toxicity, as well as some challenges in treatment planning and performance, are still a matter of debate. We aim to share our experience of interdisciplinary patient management in order to deliver these regimens. We also try to evaluate the method’s toxicity and effectiveness.

【 授权许可】

CC BY