In-vitro antiproliferative and antimigration activity against MDA-MB-231 cell line of new thiazole derivatives

Cellular Therapy and Transplantation

article

Luna Al-Nackoud¹  Ramez Wannous¹ 

[1] Faculty of Pharmacy, Damascus University

关键词: Thiazole derivatives;    breast cancer;    triple negative;    cell line;    MDA-MB-231;    growth suppression;    anti-migratory effect.;   

DOI  :  10.18620/ctt-1866-8836-2022-11-2-99-106

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Extensive studies are performed in order to develop more safe and selective anticancer drugs in terms of decreasing treatment-associated toxicity. Special attention has been paid to molecules containing sulfur heterocycles as they consider an important structural unit of many marketed drugs. A series of 2-amino, 5-nitrothiazole derivatives were designed by our University. We aimed for in vitro testing of three compounds upon growth rates of MDA-MB-231 cell line and its ability for migration.

【 授权许可】

CC BY