Therapeutic potential of conditioned medium derived from bone marrow mesenchymal stromal cells cocultured with hepatocytes in alleviation of CCl4-induced liver damage in mice

Cellular Therapy and Transplantation

article

Dima Joujeh¹  Abduljalil Ghrewaty¹  Adnan Almarrawi¹  Chadi Soukkarieh²  Jamal Abdul N. Darwicha³ 

[1] Department of Biotechnology Engineering, Faculty of Technical Engineering, University of Aleppo;Department of Animal Biology, Faculty of Sciences, Damascus University;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Arab International University

关键词: Mesenchymal stromal cells;    bone marrow;    hepatocytes;    co-culture;    conditioned medium;    liver damage.;   

DOI  :  10.18620/ctt-1866-8836-2022-11-2-84-92

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

Mesenchymal stromal cell-derived conditioned medium therapy is a rapidly developing field of research that seems to have a significant impact on the treatment of various diseases. In the present study, the therapeutic effect of conditioned medium derived from bone marrow mesenchymal stromal cells (BMSCs) co-cultured with hepatocytes (H/BMSCs CM) was investigated for alleviation of CCl4-induced liver damage in mice.

【 授权许可】

CC BY