Strength, corrosion resistance, and biocompatibility of ultrafine-grained Mg alloys after different modes of severe plastic deformation

7th International Conference on Nanomaterials by Severe Plastic Deformation

Dobatkin, S.V.^1,2 ; Lukyanova, E.A.^1,2 ; Martynenko, N.S.^1 ; Anisimova, N Yu^3 ; Kiselevskiy, M.V.^3 ; Gorshenkov, M.V.^1 ; Yurchenko, N Yu^4 ; Raab, G.I.^5 ; Yusupov, V.S.^2 ; Birbilis, N.^6 ; Salishchev, G.A.^4 ; Estrin, Y.Z.^1,6

Laboratory of Hybrid Nanostructured Materials, National University of Science and Technology, MISIS, Moscow

119991, Russia^1

A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow

119334, Russia^2

N.N. Blokhin Russian Cancer Research Center, Moscow

115478, Russia^3

Belgorod National Research University, Belgorod

308015, Russia^4

Ufa State Aviation Technical University, Ufa

45008, Russia^5

Department of Materials Science and Engineering, Monash University, Melbourne

VIC

3800, Australia^6

关键词: Bioresorbable materials;    Cell viability assays;    Mesenchymal stromal cells;    Microstructure examination;    Microstructure refinement;    Severe plastic deformations;    Ultimate tensile strength;    Ultrafine grained structure;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/194/1/012004/pdf
DOI  :  10.1088/1757-899X/194/1/012004

来源: IOP

【 摘 要 】

The effect of severe plastic deformation on the structure, mechanical properties, corrosion resistance, and biocompatibility of the WE43 (Mg-Y-Nd-Zr) alloy earmarked for applications as bioresorbable material has been studied. The alloy was deformed by rotary swaging (RS), equal channel angular pressing (ECAP), and multiaxial deformation (MAD). The microstructure examination by transmission electron microscopy showed that all SPD modes lead to the formation of ultrafine-grained structure with a structural element size of 0.5-1 μm and the Mg12Nd phase particles 0.3 μm in size. The microstructure refinement by all three treatments resulted in strengthening of the alloy. ECAP and MAD also raised ductility to up to 12-17%, while RS increased the ultimate tensile strength to up to 415 MPa. The study of the corrosion properties showed that SPD does not affect the electrochemical corrosion of the alloy. Its biocompatibility in vitro was estimated after incubation of the samples with red blood cells (hemolysis study), white blood cells (cell viability assay), and mesenchymal stromal cells (cell proliferation analysis). The biodegradation rate in fetal bovine serum was also evaluated. ECAP and MAD were found to cause some deceleration of biodegradation by slowing down the gas formation in the biological fluid and, compared to MSC, to improve the biocompatibility of the WE43 alloy.