Influência do colágeno tipo I na propriedade físico-química, morfológica e biológica de blendas poliméricas de PLGA para aplicação oftálmica

Materia

article

André de Barros Ferreira¹  Ana Flávia Rodrigues Sales¹  Sidney Nicodemos da Silva¹  Kátia Michelle Freitas¹ 

[1] Centro Federal de Educação Tecnológica de Minas Gerais

关键词: Blends;    PLGA;    collagen;    biomaterials;    delivery system of drugs;   

DOI  :  10.1590/1517-7076-RMAT-2021-45885

学科分类：工程和技术（综合）

来源: Universidade Federal do Rio de Janeiro * Coordenacao dos Programas de Pos-Graduacao de Engenharia

【 摘 要 】

Biodegradable implants associated to the drug delivery system are promising for the successful treatment of ophthalmic diseases. Among these materials used for the development of ophthalmic devices, collagen has unique and considerable properties in biomedicine, such well-known biocompatibility and safety. The present study developed polymeric blends and investigated the influence of collagen on thermal, chemical, morphological and biological characteristics in combination with PLGA (polylactic-co-glycolic acid). The blends were obtained in different proportions of PLGA and collagen: P75C25 (75% PLGA and 25% collagen) and P50C50 (50% PLGA and 50% collagen). In X-ray diffractometry (XRD) and Fourier transform infrared spectrometry analysis (FTIR), the obtained products preserved the amorphous property and revealed similar of bands absorption spectrum profiles compared the polymeric matrices. The increase in collagen is inversely proportional to reduced the thermal degradation temperature peak without maximum loss of material mass, contrary to the observed in the P75C25 sample. In addition, P50C50 showed low wettability in relation to P75C25, so less hydration that contributed to the controlled degradation of the blend and a heterogeneous morphology. In the biological characterization, both samples showed hemocompatible characteristics, preserved the morphology of isolated lymphocytes and no induction of oxidative stress was observed. Thus, polymeric blends could used potentially as multifunctional platform aimed at drug-entrapment and delivery system.

【 授权许可】

CC BY