Pancreatic cancer survival trends in the US from 2001 to 2014: a CONCORD-3 study

Cancer Communications

article

Maja Nikšić¹  Pamela Minicozzi¹  Hannah K Weir³  Heather Zimmerman⁴  Maria J Schymura⁵  Judith R Rees⁶  Michel P Coleman¹  Claudia Allemani¹  US CONCORD Working Group⁸ 

[1] Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine;Centre for Health Services Studies, University of Kent;Division of Cancer Prevention and Control, Centers for Disease Control and Prevention;Montana Central Tumor Registry, Chronic Disease Prevention and Health Promotion Bureau;Bureau of Cancer Epidemiology, New York State Cancer Registry, New York State Department of Health;New Hampshire State Cancer Registry, Norris Cotton Cancer Center, and Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Dartmouth-Hitchcock Medical Center, One Medical Center Drive;Cancer Division, University College London Hospitals NHS Foundation Trust;US CONCORD Working Group members are listed at the end of the article

关键词: pancreatic cancer;    race/ethnicity;    stage;    net survival;    population-based cancer registries;   

DOI  :  10.1002/cac2.12375

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Background Survival from pancreatic cancer is low worldwide. In the US, the 5-year relative survival has been slightly higher for women, whites and younger patients than for their counterparts, and differences in age and stage at diagnosis [Corrections added Nov 16, 2022, after first online publication: a new affiliation is added to Maja Nikšić] may contribute to this pattern. We aimed to examine trends in survival by race, stage, age and sex for adults (15-99 years) diagnosed with pancreatic cancer in the US.Methods This population-based study included 399,427 adults registered with pancreatic cancer in 41 US state cancer registries during 2001-2014, with follow-up to December 31, 2014. We estimated age-specific and age-standardized net survival at 1 and 5 years.Results Overall, 12.3% of patients were blacks, and 84.2% were whites. About 9.5% of patients were diagnosed with localized disease, but 50.5% were diagnosed at an advanced stage; slightly more among blacks, mainly among men. No substantial changes were seen over time (2001-2003, 2004-2008, 2009-2014). In general, 1-year net survival was higher in whites than in blacks (26.1% vs. 22.1% during 2001-2003, 35.1% vs. 31.4% during 2009-2014). This difference was particularly evident among patients with localized disease (49.6% in whites vs. 44.6% in blacks during 2001-2003, 60.1% vs. 55.3% during 2009-2014). The survival gap between blacks and whites with localized disease was persistent at 5 years after diagnosis, and it widened over time (from 24.0% vs. 21.3% during 2001-2003 to 39.7% vs. 31.0% during 2009-2014). The survival gap was wider among men than among women.Conclusions Gaps in 1- and 5-year survival between blacks and whites were persistent throughout 2001-2014, especially for patients diagnosed with a localized tumor, for which surgery is currently the only treatment modality with the potential for cure.

【 授权许可】

CC BY|CC BY-NC-ND