Salvation for Stalled Ribosomes: tmRNA and $trans$-translation in $Escherichia coli$

Resonance

article

T Nagarajan¹  N Arul Muthu Kumaran¹  M Hussain Munavar¹ 

[1] Former Professor and Head Department of Molecular Biolog y School of Biological Sciences Madurai Kamaraj Universit y Madurai 625 021

关键词: tmRNA-SmpB complex;    ribosome rescue;    SsrA;    $trans$-translation.;   

DOI  :  10.1007/s12045-023-1605-5

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Ribosomes stall indefinitely at the 3' end of the mRNAs that lack natural stop codon and also pause anywhere on normal mRNAs during starvation. This pausing traps a considerable population of ribosomes in an inactive state and leads to a deficiency of ribosomes for ongoing protein synthesis. Bac­teria possess a special RNA molecule called the tmRNA (a chimera of tRNA and mRNA), which in association with its binding partner SmpB protein, rescues the stalled ribosomes in a complex multistep process called $trans$-translation. This review aims to discuss the process of $trans$-translation and its involvement in regulating macromolecular processes in bac­teria.

【 授权许可】

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