High-Resolution Silicon Photomultiplier Time-of-Flight Dedicated Head PET System for Clinical Brain Studies

The Journal of Nuclear Medicine

article

Kazunari Ishii¹  Kohei Hanaoka²  Shota Watanabe²  Daisuke Morimoto-Ishikawa²  Takahiro Yamada²  Hayato Kaida¹  Yoshiyuki Yamakawa³  Suzuka Minagawa³  Shiho Takenouchi³  Atsushi Ohtani³  Tetsuro Mizuta³ 

[1] Department of Radiology, Kindai University Faculty of Medicine;Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University Hospital;Medical Systems Division

关键词: high resolution;    silicon photomultiplier;    time of flight;    dedicated head PET;    brain;   

DOI  :  10.2967/jnumed.122.264080

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

We acquired brain 18F-FDG and 18F-flutemetamol PET images using a time-of-flight system dedicated to the head (dhPET) and a conventional whole-body PET/CT (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. Methods: There were 18 subjects for the 18F-FDG PET study and 17 subjects for the 18F-flutemetamol PET study. 18F-FDG PET images were first obtained using wbPET, followed by dhPET. 18F-flutemetamol PET images were first obtained using wbPET, followed by dhPET. Images acquired using dhPET and wbPET were compared by visual inspection, voxelwise analysis, and SUV ratio (SUVR). Results: All 18F-FDG and 18F-flutemetamol images acquired using dhPET were judged as visually better than those acquired using wbPET. The voxelwise analysis demonstrated that accumulations in the cerebellum, in the lateral occipital cortices, and around the central sulcus area in dhPET 18F-FDG images were lower than those in wbPET 18F-FDG images, whereas accumulations around the ventricle systems were higher in dhPET 18F-FDG images than those in wbPET 18F-FDG images. Accumulations in the cerebellar dentate nucleus, in the midbrain, in the lateral occipital cortices, and around the central sulcus area in dhPET images were lower than those in wbPET images, whereas accumulations around the ventricle systems were higher in dhPET 18F-flutemetamol images than those in wbPET 18F-flutemetamol images. The mean cortical SUVRs of 18F-FDG and 18F-flutemetamol dhPET images were significantly higher than those of 18F-FDG and 18F-flutemetamol wbPET images, respectively. Conclusion: The dhPET images had better image quality by visual inspection and higher SUVRs than wbPET images. Although there were several regional accumulation differences between dhPET and wbPET images, understanding this phenomenon will enable full use of the features of this dhPET system in clinical practice.

【 授权许可】

CC BY